Using a comprehensive set of simulations with the Max Planck Institute for Meteorology Earth System Model, we disentangle and quantify the impacts of a disintegrated Greenland Ice Sheet (GrIS) on the global climate, including the deep ocean. We find most of the climate response is driven by Greenland’s lower elevation and enhanced by changed surface properties, although regional differences exist. Despite the confinement of most responses to the Arctic, the GrIS also influences remote climates.