Reducing non-CO₂ greenhouse gases is important alongside CO₂ for climate mitigation. Here, we look at how reducing their emissions compares to reducing CO₂ using an Earth system model. While both types of gases contribute to warming, their regional climate impacts differ. Besides, the carbon cycle responds differently depending on whether climate change is driven by CO₂ or non-CO₂ gases. Considering both types of gases is important for carbon cycle analysis and climate mitigation strategies.